University of Bristol Scientists Make Breakthrough in Early Disease Detection
By Health Correspondent
Scientists at the University of Bristol say they have discovered a new way to detect the earliest signs of heart and kidney disease using a simple blood test.
The research, published in Nature Communications, focuses on damage to tiny blood vessels that can occur long before serious illness develops.
Researchers found they could identify this damage by analysing changes to the glycocalyx – a thin protective coating that lines blood vessels and helps regulate the movement of cells and substances through the bloodstream.
The team discovered that red blood cells carry a biochemical “imprint” of this coating, potentially allowing doctors to detect disease much earlier than current methods, which often rely on invasive biopsies.
Dr Matthew Butler said:
“Our results suggest that we can use changes occurring at the surface of red blood cells to identify microscopic blood vessel damage before other markers become detectable.
“Most excitingly, we can also rapidly detect when drugs are effective at restoring the blood vessel lining.”
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Researchers believe the findings could improve early diagnosis and treatment for conditions including heart and kidney disease.
Professor Simon Satchell added:
“This discovery could pave the way for proactive, preventative healthcare, offering the possibility of addressing diseases before they develop.”
The study was funded by organisations including the MRC, Kidney Research UK and the British Heart Foundation.
